Search results for " 5-HT1B"

showing 4 items of 4 documents

CB1 cannabinoid receptor-mediated aggressive behavior

2013

This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT). Gene expression analyses of monoaminooxidase-A (MAO-A), catechol-o-methyl-transferase (COMT), 5-hydroxytriptamine transporter (5-HTT) and 5-HT1B serotonergic receptor (5HT1Br) in the median and dorsal raphe nuclei (MnR and DR, respectively) and in the amygdala (AMY) were performed by real time-PCR. Double immunohistochemistry studies evaluated COMT and CB1r co-localization in the raphe nuclei and in the cortical (AC…

AgonistMalemedicine.medical_specialtyCannabinoid receptorTime Factorsmedicine.drug_classmedicine.medical_treatmentPoison controlArachidonic AcidsSerotonergicCatechol O-MethyltransferaseAmygdalaCellular and Molecular NeuroscienceMiceDorsal raphe nucleusReceptor Cannabinoid CB1Internal medicinemedicineAnimalsInterpersonal RelationsMonoamine OxidasePharmacologyCannabinoid Receptor AgonistsMice KnockoutSerotonin Plasma Membrane Transport ProteinsAmygdalaSurgeryAggressionmedicine.anatomical_structureEndocrinologynervous systemGene Expression RegulationImpulsive BehaviorReceptor Serotonin 5-HT1BConditioning OperantRaphe NucleiCannabinoidRaphe nucleiPsychologyReinforcement Psychology
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The HTR1B 861GC receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy.

2000

Abstract The HTR1B receptor gene has been linked to antisocial alcoholism in a Finnish population and an American Indian tribe [Lappalainen et al., Arch. Gen. Psychiatry, 55 (1998) 989]. Using a candidate gene approach, we genotyped 209 patients with alcoholism, 108 patients with major depression, 32 patients with panic disorder, 50 patients with generalized anxiety disorder, 58 patients with narcolepsy and 74 healthy volunteers for the HTR1B 861G>C polymorphism. There was a higher frequency of the HTR1B 861G alleles among the alcohol-dependent patients as compared to the control subjects (χ 2 =4.02, d.f.=2, P =0.04). However, the association resulted from higher frequencies of the opposite…

AdultMaleRiskCandidate genemedicine.medical_specialtyGeneralized anxiety disorderGenotypeInternal medicineGermanymedicineHumansPsychiatryTemperamentBiological PsychiatryPsychiatric geneticsAllelesNarcolepsyDepressive Disorder MajorPolymorphism GeneticPanic disorderPanicmedicine.diseaseAnxiety DisordersPsychiatry and Mental healthAlcoholismPhenotypeCase-Control StudiesReceptors SerotoninReceptor Serotonin 5-HT1BAnxietyPanic DisorderChromosomes Human Pair 6Femalemedicine.symptomPsychologyAnxiety disorderNarcolepsyPsychiatry research
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5-HT3 receptor-channels coupled with Na+ influx in human T cells: role in T cell activation.

1999

The study was conducted on a human (Jurkat) T cell line, loaded with a Na+ fluorescent probe, SBFI/AM. Serotonin and an agonist of 5-HT3 receptor-channels, 2-methyl-5HT, evoked Na+ influx, whereas the agonists of other serotonergic receptor subtypes, i.e., 5-HT1A and 5-HT1B receptors, failed to induce Na+ influx in these cells. By using 3H-BRL43694, an agonist of 5-HT3 receptor-channels, we characterized 5-HT3 lymphocyte receptors which exhibited a density (Bmax) of 300 +/- 20 fmol/10(6) cells and a Kd of 30 nM in Jurkat T cells. The T-cell 5-HT3 receptor-channel is not regulated either by the protein kinase C or by the free intracellular calcium concentrations as the agents known to activa…

AgonistSerotoninmedicine.drug_classMetoclopramideT cellT-LymphocytesImmunologyBiologyLymphocyte ActivationJurkat cellsCalcium in biologyPiperazinesSodium ChannelsGranisetronJurkat CellsQuinoxalinesmedicineImmunology and AllergyHumansCalcium SignalingPhytohemagglutininsReceptorProtein kinase C5-HT receptorProtein Kinase C8-Hydroxy-2-(di-n-propylamino)tetralinIon TransportRyanodineCell CycleSodiumCell biologyNeoplasm ProteinsSerotonin Receptor AgonistsEnzyme Activationmedicine.anatomical_structureNeurologyReceptors SerotoninReceptor Serotonin 5-HT1BThapsigarginNeurology (clinical)Serotonin AntagonistsReceptors Serotonin 5-HT3Ion Channel GatingReceptors Serotonin 5-HT1IntracellularJournal of neuroimmunology
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Photochemistry of 1,2,4-oxadiazoles. A DFT study on photoinduced competitive rearrangements of 3-amino- and 3-N-methylamino-5-perfluoroalkyl-1,2,4-ox…

2006

The photoinduced competitive rearrangements of 5-perfluoroalkyl-3-amino(N-alkylamino)-1,2,4-oxadia- zoles have been investigated by DFT calculations and UV-vis spectroscopy. The observed product selectivity depends on the number of hydrogen atoms present in the amino moiety and involves two or three possible routes: (i) ring contraction-ring expansion (RCRE), (ii) internal-cyclization isomerization (ICI), or (iii) C(3)-N(2) migration-nucleophilic attack-cyclization (MNAC). UV absorption and fluorescence spectra of the reactants, and vertical excitation energy values, calculated by time dependent DFT, support the involvement of a neutral singlet excited state in the photoexcitation process. …

PhotochemistryUltraviolet RaysFluorescence spectrometryReaction intermediatePhotochemistryDENSITY-FUNCTIONAL THEORYSinglet stateHUMAN 5-HT1B RECEPTORBASIS-SETSOxadiazolesRING-PHOTOISOMERIZATIONMolecular StructureChemistryOrganic ChemistryEXPEDIENT ROUTETautomerTransition statePhotoexcitationMOLECULAR-ORBITAL METHODSModels ChemicalLUORINATED HETEROCYCLIC-COMPOUNDSAROMATICITY INDEXExcited state5-MEMBERED HETEROCYCLESEXCITATION-ENERGIESIsomerization
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